What tumors need
نویسنده
چکیده
Dog thyroids and guinea pig eyes Judah Folkman’s radical idea began with a mundane task. In 1961, Folkman, then a third year surgical resident, was drafted by the navy and charged with optimizing the use of freeze-dried hemoglobin as an alternative to fresh blood. The hemoglobin preparations were tested for the ability to sustain the viability of dog thyroid glands and, later, the growth of mouse tumor cells implanted in the glands. The implanted tumors stopped growing after reaching a modest size, but grew explosively if transplanted back into a mouse. Intrigued, Folkman examined the tumors under the microscope and found a network of tiny blood vessels inside the retransplanted tumor cells. He saw no vessels in the original thyroid tumors (1). The data were consistent with work from Harry Greene, who had shown long before that growth of rabbit tumors transplanted into the anterior chamber of the guinea pig eye coincided with the growth of new blood vessels (angiogenesis). Tumors that remained viable but did not grow had no visible blood supply (2). Folkman thus proposed that angiogenesis and tumor growth might go hand in hand. He even stuck his neck out and speculated that “anti-angiogenesis” strategies might eventually be used to treat cancer (3). These ideas were widely criticized, as the prevailing opinion at that time was that tumor growth did not depend on angiogenesis.
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 201 شماره
صفحات -
تاریخ انتشار 2005